Map3k5 CLIA Kit for Mouse(Mus musculus) | EIAab.comMap3k5 CLIA Kit for Mouse(Mus musculus)

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Map3k5 (Gene name),

Mitogen-activated protein kinase kinase kinase 5 (Protein name ), M3K5_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Map3k5(Ask1;Mekk5);

Protein name:

Mitogen-activated protein kinase kinase kinase 5;

Alternative:

MAPK/ERK kinase kinase 5(MEK kinase 5;MEKK 5);Apoptosis signal-regulating kinase 1(ASK-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with DAB2IP (By similarity). Interacts with PPM1L. Interacts with ARRB2. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis.

Function:

Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1380

Sequence:

50:

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1250:

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1380:

VTRDDLKCLR | LRGGMLCTLW | KAIIDFRNKC |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF13281

UniGene:

Mm.6595

KEGG:

mmu:26408

String:

O35099

Pfam:

PF00069

SMR:

O35099

STRING:

10090.ENSMUSP00000093485

Uniprot:

O35099

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ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 5

Cat.:

E1358h

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96T

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ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 5

Cat.:

E1358m

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Packing:

96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 5

Cat.:

U1358h

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Packing:

96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 5

Cat.:

U1358m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 5

Cat.:

P1358Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 5

Cat.:

P1358Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 5

Protein for Mouse Mitogen-activated protein kinase kinase kinase 5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1."
Tobiume K. , Inage T. , Takeda K. , Enomoto S. , Miyazono K. , Ichijo H.
Biochem. Biophys. Res. Commun.239:905-910(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
2.

Tobiume K. , Inage T. , Takeda K. , Enomoto S. , Miyazono K. , Ichijo H.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 22-26; 123; 273; 755; 1001-1011; 1220-1222 AND 1274-1280
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis."
Tobiume K. , Matsuzawa A. , Takahashi T. , Nishitoh H. , Morita K. , Takeda K. , Minowa O. , Miyazono K. , Noda T. , Ichijo H.
EMBO Rep.2:222-228(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer."
Tobiume K. , Saitoh M. , Ichijo H.
J. Cell. Physiol.191:95-104(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-845 AND THR-849;ENZYME REGULATION
6.

"Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation."
Takeda K. , Matsuzawa A. , Nishitoh H. , Tobiume K. , Kishida S. , Ninomiya-Tsuji J. , Matsumoto K. , Ichijo H.
EMBO Rep.5:161-166(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity."
Matsuzawa A. , Saegusa K. , Noguchi T. , Sadamitsu C. , Nishitoh H. , Nagai S. , Koyasu S. , Matsumoto K. , Takeda K. , Ichijo H.
Nat. Immunol.6:587-592(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;INTERACTION WITH TRAF6
8.

"A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation."
Rubiolo C. , Piazzolla D. , Meissl K. , Beug H. , Huber J.C. , Kolbus A. , Baccarini M.
Blood108:152-159(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth."
Liu Q. , Wilkins B.J. , Lee Y.J. , Ichijo H. , Molkentin J.D.
Mol. Cell. Biol.26:3785-3797(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP3R1;PHOSPHORYLATION AT SER-973;ENZYME REGULATION;FUNCTION
10.

"Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon."
Saito J. , Toriumi S. , Awano K. , Ichijo H. , Sasaki K. , Kobayashi T. , Tamura S.
Biochem. J.405:591-596(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPM1L
11.

"Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation."
Jung H. , Seong H.A. , Ha H.
J. Biol. Chem.283:34541-34553(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-845
12.

"Apoptosis signal-regulating kinase 1 in stress and immune response."
Takeda K. , Noguchi T. , Naguro I. , Ichijo H.
Annu. Rev. Pharmacol. Toxicol.48:199-225(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
13.

"The roles of ASK family proteins in stress responses and diseases."
Hattori K. , Naguro I. , Runchel C. , Ichijo H.
Cell Commun. Signal.7:9-9(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
14.

"S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."
Yamaguchi F. , Umeda Y. , Shimamoto S. , Tsuchiya M. , Tokumitsu H. , Tokuda M. , Kobayashi R.
J. Biol. Chem.287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP5C;PHOSPHORYLATION AT THR-845;DEPHOSPHORYLATION AT THR-845 BY PPP5C

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